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PENELOPE-B is a validated risk assessment tool combining: clinical stage before neoadjuvant treatment, grading and estrogen-receptor status. CDK inhibitors, including their potential benefits, that involves substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. The CPS-EG is a validated risk assessment tool combining: clinical stage before neoadjuvant treatment, grading and estrogen-receptor status.